Generic Arava - Leflunomide
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Generic Equivalent To Brand Name Arava
Name : Leflunomide
Dosage : 20mg
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CLASS and MECHANISM of Action
Generic Arava is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.
It is available for oral administration as tablets containing 10 and 20mg of active drug.
Generic Arava is an immunomodulatory drug inhibiting dihydroorotate dehydrogenase (an enzyme involved in de novo pyrimidine synthesis) (abbreviation DHODH). Genuine antiproliferative activity has been proven. Additionally, several experimental models (both in vivo and in vitro) have demonstrated an anti-inflammatory effect. This double action is supposed to slow progression of the disease and to cause remission/relief of symptoms of rheumatoid arthritis and psoriatic arthritis such as joint tenderness and decreased joint and general mobility in human patients.
Active Ingredients: Leflunomide
Inactive Ingredients: macrogol, magnesium stearate, crospovidone, hypromellose, lactose, silica colloidal anhydroustalc, maize starch, povidone, titanium dioxide.
What is Generic Arava PRESCRIBED For?
Generic Arava is indicated in adults for the treatment of:
- active moderate to severe rheumatoid arthritis and psoriasis arthritis;
- to reduce signs and symptoms;
- to inhibit structural damage as evidenced by X-ray erosions and joint spacenarrowing;
- to improve physical function.
How Should I Take Generic Arava?
This medicine is administrated orally. Usually it is taken once daily. Dosing is based on your medical conditions, response to therapy, and liver function test results. Follow the directions of your health care professional carefully. Generally it is recommended to start with a special higher dose for the first 3 days, then decrease to the regular dose thereafter. The onset of clinical improvement can be expected after 4 to 6 weeks of continued therapy.
After treatment is stopped, cholestyramine may be given as directed, generally three times daily for 11 days. This procedure is used if you require a rapid removal of the drug from your system. Without the procedure the drug may persist for 2 years. Consult your doctor or pharmacist to learn whether you are a candidate for cholestyramine treatment (such as a couple planning to have children).
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture and light.
Do not store in the bathroom, near the kitchen sink, or in other damp places.
Heat or moisture may cause the medicine to break down.
What are the CONTRAINDICATIONS for taking Generic Arava?
Generic Arava is contraindicated to patients with hypersensitivity to Generic Arava or to any of the excipients in the tablets.
Generic Arava should not be administrated to:
Persons that are taken Generic Arava should avoid people with colds, flu, and bronchitis because they are more susceptible to infection.
- patients with severe immunodeficiency states, e.g. AIDS;
- patients with significantly impaired bone marrow function or significant anaemia, leukopenia or thrombocytopenia due to causes other than rheumatoid arthritis;
- patients with severe, uncontrolled infections ;
- patients with impairment of liver function;
Vaccinations are containdicated.
Your health care professional should be notified if you are going to have surgery or plan to go to a dentist.
Alcoholic drinks can make you more dizzy and increase possible damage to your liver. Avoid alcoholic drinks while taking Generic Arava.
Generic Arava is contraindicated to women that are pregnant, plan to be pregnant or that are breast-feeding. Generic Arava has been shown to cause birth defects to the fetus. If you suspect or find out that you are pregnant while taking Generic Arava, call your health care professional right away. After stopping Generic Arava treatment, you must complete the drug elimination procedure before becoming pregnant because Generic Arava stays in the body a long time.
What Happens if I MISS A DOSE?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take your next regularly scheduled dose.
NOTE: Do not take a double dose of this medication unless otherwise directed by your health care professional.
What happens if I OVERDOSE?
Symptoms of overdose with Generic Arava leukopenia, diarrhoea, abdominal pain, anaemia and elevated liver function tests.
If an overdose is suspected seek emergency medical attention immediately.
What are the possible SIDE EFFECTS of Generic Arava?
Your health care professional should be informaed immediately if you experience:
- back pain;
- mouth sores;
- hair loss;
- chest pain;
- muscle cramping;
- numbness/tingling sensations;
- unusual lumps (lymph gland enlargement).
If any of the below effects persist notify your health care professional or pharmacist promptly:
If signs of infection (such as fever), extreme weakness/fatigue, or easy bruising/bleeding develop appear consult your doctor as soon as possible.
- nausea or vomiting;
- mild dizziness;
- stomach/abdominal pain;
- dark urine;
- yellowing eyes/skin develop.
In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
What other drugs can INTERACT with Generic Arava?
Be sure to inform your health care professional about all of the medications you are taking, including over-the-counter drugs and natural remedies, as these may reduce the effectiveness of Generic Arava.
The following medications are among those that may interfere with Generic Arava:
Cholestyramine and charcoal decrease the concentration of the active form of Generic Arava in the blood probably by preventing absorption. Rifampin increases the blood concentration of the active form of Generic Arava by 40% probably by increasing the conversion of Generic Arava to its active form. This may increase the side effects of Generic Arava.
- cholestyramine (Questran);
- tolbutamide (Orinase);
- rifampin (Rifadin or Rimactane).
Keep out of the reach of children in a container that small children cannot open.
Do not share this medicine with others for whom it was not prescribed.
Throw away any unused medicine after the expiration date.
Do not keep outdated medicine or medicine no longer needed.
Do not use this medicine for other health conditions.